Computational Genomics Research Scientist

Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation. They are seeking a computational biologist to join their Data and Computational Sciences organization, where the role involves leveraging computational biology to accelerate the development of transformative therapies for serious human diseases. Responsibilities Proactively collaborate with cross‑functional project teams as the computational biology expert to identify key scientific questions that can be addressed through human genetics, genomics, sequencing, and computational analyses Design and execute studies across diverse omics, including bulk RNA‑seq, whole‑genome sequencing, single‑cell RNA‑seq, spatial transcriptomics, and human genetics Perform sophisticated computational analyses of internal and external datasets, integrating deep critical thinking, statistical rigor, domain expertise, and best practices from the literature to generate actionable insights Incorporate publicly available genomic resources (e.g., GTEx, gnomAD, FinnGen, UK Biobank) to contextualize and interpret internal data Distill complex analyses and scientific results into clear presentations, including key take-home messages and recommendations for next steps to a broad audience Author study reports, white papers, and manuscripts to support internal decision-making and external communications including regulatory filings Partner with the DCS method development team to develop innovative methods and improve usability, accuracy, and robustness of existing ones Skills PhD degree (or Master's degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field with 0–3 years (or 3+ years for Master's degree) of productive, relevant industry or post-doc experience A proven track record of stand-out excellence in the analysis, visualization, and interpretation of genomic data (such as next-generation sequencing (NGS)) or human genetic data Demonstrated ability to work across cross-functional teams, ensuring timely progress Superior communication skills, demonstrating confidence and versatility in presenting verbally to diverse audiences and writing technical documents Deep scientific understanding of genetic variation in human disease, molecular biology, and cellular biology Expertise with rapidly applying computational methods and bioinformatics tools to large-scale data Proficiency with R and/or python, and high-performance computing systems; solid understanding of statistics A team-oriented growth mindset that welcomes feedback from others and supports other team members; a positive attitude that enthusiastically tackles and overcomes challenges A proven track record in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) data Solid scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biology Expertise with applying computational methods and bioinformatics tools to large-scale data Solid understanding of statistics Benefits Medical, dental and vision benefits Generous paid time off (including a week-long company shutdown in the Summer and the Winter) Educational assistance programs including student loan repayment A generous commuting subsidy Matching charitable donations 401(k) Company Overview Vertex Pharmaceuticals is focused on the discovery and development of small molecule drugs for the treatment of serious diseases. It was founded in 1989, and is headquartered in Boston, Massachusetts, USA, with a workforce of 5001-10000 employees. Its website is Company H1B Sponsorship Vertex Pharmaceuticals has a track record of offering H1B sponsorships, with 188 in 2025, 150 in 2024, 111 in 2023, 164 in 2022, 112 in 2021, 80 in 2020. Please note that this does not guarantee sponsorship for this specific role.